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Tobicom (Sodium chondroitin sulfate 100mg, Vitamins, Minerals)


Formula
Each capsule contains:
Active ingredients
Sodium chondroitin sulfate 100 mg
Retinol palmitate 2500 I.U.
Choline hydrogen tartrate   25 mg
Riboflavin 5 mg
Thiamine hydrochloride 20 mg
Excipients
Tocopherol, lactose, colloidal anhydrous silica, glucose, magnesium stearate and green capsule shell.

Dosage form
Capsule.

Presentation
Box contains 3 packets x 6 blisters x 10 capsules.

Indications
Fatigue of eyes, keratitis, ophthalmoplegia, amblyopia during lactation, nyctalopia, nutritional supplements in decreased vision.

Contra-indications
Hypersensitivity to any component of the drug. Do not concomitantly administer with other medications containing vitamin A.

Dosage and Administration
Adults: one capsule; once or twice a day.
Children from 12 years old: one capsule a day.

Warnings
Dose of vitamin A should not exceed by 5000 I.U. a day in pregnant women due to the danger of inducement of congenital malformation.

Precautions
- Recommended dosage and administration should be observed.
- It should be administered to children under an adult's guidance.
- It should be kept out of the reach of children.
- The adequate amount of vitamin A usually obtained from dietary sources, therefore, dose of vitamin A should not exceed 5000 I.U. a day.
- Persons who are under treatment by doctors and pregnant women should consult with doctors or pharmacists before administration of the product.

Side effects
Nausea, vomiting, diarrhea, pruritus. When these symptoms are diagnosed, discontinue and consult with doctors or pharmacists.
Inform your doctors side effects, if any, during the treatment with TOBICOM.

Drug interactions
Neomycin, cholestyramine, liquid paraffin may reduce the body’s ability to absorb vitamin A. Oral contraceptives increase plasma levels of vitamin A. It should not be used by women who want to get pregnant. This drug should not be taken while using isotretinoin.

Overdosage
In case of overdose, it may cause melosalgia, hypersensitivity, delpilation, anorexia, loss of weight, headache, diarrhea, vomiting. If the symptoms occur, discontinue and consult your doctors or pharmacists.

Pharmacokinetic
Sodium chondroitin sulphate increase stability of intracellular collagen, therefore, it stabilizes the neuron of ocular muscles, eyeslash muscle,etc..and maintains the stability of transparent in terstic, and restores or maintains the flexibility of hardened optic lens.
Choline bitartrate, retinol palmitate, thiamine hydrochloride and riboflavin are as essential vitamins for the development and maintenance of epithelial tissue, and for vision, they restore the function of ocular muscles, protect cornea and prevent from aging of eyes.

Pharmacodynamic
Oral administration of sodium chondroitin sulphate produces a peak of serum level at 6-8 hours with detectable levels persisting for 24 hours.
Urinary excretion after administration from 50 to 60 percent and sodium chondroitin sulphate is as a mucopolysaccharide which is constituent of most mammalian cartilaginous tissues.

Storage
Store in a dry and cool place (< 25 degree C), protect from light.

Shelf-life
24 months.


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